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Pharmacology: Pharmacodynamics: The synergistic anti-ovulatory effect from the combined use of Gestodene and Ethinyl estradiol directly decreases the secretion of the gonadotropin-releasing hormone (GnRH) from the hypothalamus and is considered the main action. This negative feedback mechanism disrupts ovulation by interfering with the hypothalamus pituitary-ovary axis and gonadotropin secretion from the pituitary. Specifically, the gestodene component blunts or suppresses luteinizing hormone (LH) release and the LH surge, which is necessary for ovulation, and the estrogen component blunts or suppresses the follicle-stimulating hormone (FSH), which prevents the selection and maturatuion of the dominant follicle.
Pharmacokinetics: Both Gestodene and Ethinyl estradiol are rapidly and well absorbed and widely distributed. Ethinyl estradiol is excreted by renal (22 to 58%), fecal (30 to 53%), biliary (26 to 43%).
